Table 4.

Changes in Cortical Thickness (percent of baseline) in BtxA or Saline Injected Limbs Relative to Non-Injected Control Limbs

Weeks since Injection	3	7	11	15	19
WT Saline	5.09±4.09	−0.58±4.34	−0.11±4.87	6.64±4.63	3.19±3.49
WT BtxA*	−15.03±1.88ab	−10.42±4.91	−14.44±2.42a	−9.02±4.15	−5.28±5.23
cKO Saline	3.32±1.99	5.01±3.11	6.83±5.55	6.72±6.52	9.17±5.27
cKO BtxA*	−3.86±4.87	−4.07±3.25	−4.12±3.04	1.02±5.51	3.63±3.21

WT: wild type mice; cKO: osteoblast/osteocyte conditional Gja1 knockout mice

^*significant effect of treatment (two way ANOVA);

^ap < 0.05 vs. cKO Saline;

^bp < 0.05 vs. WT Saline.