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Activation of the TLR3 pathway. Endosomal poly(I:C)-bound TLR3 activates Toll/IL1R-domain containing adapter-inducing interferon beta, a TLR adaptor molecule as well as members of the TRAF family, leading to the activation of the TBK1–IKKε complex. This complex phosphorylates IRF3 and IRF7, transcription factors that regulate IFN response genes such as IFN-β and IP-10. ISRE: interferon-stimulated response elements.
