Table 10.

Binding and intracerebroventricular antinociception as a function of helix stability: glucopeptides.

Compound	Message sequence	Link	Helical address sequence	Ki (nM)			A50
				δ receptor	μ receptor	κ receptor	Intracerebroventricular (nmol)
41*	YtFGL	P	NLBEKBLKS*L-NH2	11	9.1	6.9	1.13
42*/33	YtFGL	P	NLBEKALKS*L-NH2	3.6	2.3	2.6	0.58
43*	YtFGL	P	NLAEKBLKS*L-NH2	14	6.1	12	1.46
44*	YtFGL	P	NLAEKALKS*L-NH2	7.9	6.2	8.9	1.44
45*	YtFGL	P	NLAEKGLKS*L-NH2	6.3	2.2	6.3	1.47
46*	YtFGL	P	NLGEKALKS*L-NH2	5.7	2.9	11	2.54
47*	YtFGL	P	NLGEKGLKS*L-NH2	7.1	3.5	4.4	2.12

S = OH; S* = Glc; S** = Lact.

P: Proline; S: Serine.