. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Thromb Haemost. 2011 Oct 6;106(5):849–857. doi: 10.1160/TH11-05-0330

Table 1.

Mouse Models of SLE-Accelerated Atherosclerosis

Animal Model	Diet	Increased Atherosclerosis	Renal disease	Cholesterol	Splenomegaly	Antibody Production	Other Findings
gld. apoE^-/- [31]	Western Diet (12 wks)	Yes	Yes	↓	Yes	Yes	•↑ apoptosis •Impaired clearance of apoptotic debris
gld. apoE^-/- [31]	Chow diet (12 wks)	Yes	Yes	↓	Yes	Yes	•↑ apoptosis •Impaired clearance of apoptotic debris
LDLr.Sle1.2.3 [37, 38]	Western diet (8 wks) [37]	Yes	Yes	↓	Yes	Yes	•↑ T cell activation •↑ Tcell accumulation in plaque
LDLr.Sle1.2.3 [37, 38]	Chow diet (8 wks) [38]	Yes	Yes	↓	Yes	Yes	•↑ T cell activation •↑ Tcell accumulation in plaque
apoE^-/-Fas^-/- [32]	Chow diet (5 mos.)	Yes	Yes	↓	Yes	Yes	• Ostopenia • Accumulation of apoptotic debris
MRL/lpr. apoE^-/- [33]	Chow diet (24 wks)	Yes	n/a	↑	n/a	Yes	-
cGVHD induced lupus in apoE^-- mice [33]	Chow diet (24 wks)	Yes	n/a	↔	n/a	Yes	• ↓ marginal zone B cells