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. 2012 Feb;14(2):159–168. doi: 10.1593/neo.111440

Figure 3.

Figure 3

(A) Effects of bexarotene on oleate uptake in intestinal mucosa of male mice. A modest uptake of oleate was observed in colonic mucosa from male mice treated with 60 but not 30 ppm of bexarotene compared with that in the untreated animals. (B) Effects of bexarotene on oleate uptake in intestinal mucosa of female mice. A significant uptake of oleate (P < .008 to P < .01) was observed in the colonic mucosa from female mice mouse treated with 30 or 60 ppm of bexarotene compared with that in untreated animals. (C) Modulatory effects of bexarotene on RXR-α, COX-2, and cyclin D1 mRNA expression in SI polyps of treated and untreated ApcMin/+ male mice. A significant dose-dependent increased expression of RXR-α mRNA was observed on bexarotene treatment (30 and 60 ppm). A significant dose-dependent suppression of COX-2 and cyclin D1 mRNA was observed on bexarotene treatment in ApcMin/+ mice. (D) Modulatory effects of bexarotene on RXR-α, COX-2, and cyclin D1 mRNA expression in colon tumors of treated and untreated ApcMin/+ female mice. A significant dose-dependent increase in expression of RXR-α mRNA was observed on bexarotene treatment. A significant dose-dependent suppression of COX-2 and cyclin D1 mRNA was observed on bexarotene treatment (30 ppm) in ApcMin/+ mice.