Figure 8.

Estimated McKillop-Geeves parameters K_B and K_T from the best fits of the stochastic cooperative model predictions to stopped flow data for the excess [S1] to [actin] and for titrations as a function of pCa. The unit size in all simulations is N=7. The black line with grey filled square symbols is best fit by McK-G stochastic model of the stopped flow excess S1 data set, the grey line with grey triangle (down) symbols is the best fit the titration data set. For comparison K_B and K_T estimated from the probabilistic McK-G model are show as black dashed line with circle open symbols for the parameters estimated from the stopped flow excess [S1] and from the titration data sets are denoted by dark grey dashed line with triangle up symbols. Dark grey diamonds are the data from Chen et al.¹