Table 4. Prediction of cardiovascular death by backward-elimination.

	HR (95%CI)*	p
Conventional cardiovascular risk factors
age, per year	1.13 (1.10; 1.16)	<.001
Smoker	1.92 (1.13; 3.28)	0.02
Antihypertensive medication	1.15 (0.72; 1.83)	0.56
HDL cholesterol, 1-SD increase	0.77 (0.58; 1.01)	0.06
Female	0.67 (0.42; 1.07)	0.10
Diabetes	1.50 (0.83; 2.71)	0.18
Systolic BP, 1-SD increase	1.18 (0.95; 1.47)	0.13
Total cholesterol, 1-SD increase	0.95 (0.74; 1.20)	0.66
Biomarkers
HbA1c, 1-SD increase	1.28 (1.07; 1.51)	0.005
hsCRP, 1-SD increase	1.50 (1.21; 1.87)	<.001
IGF-1 <10th percentile	2.18 (1.30; 3.67)	0.003

BP  =  blood pressure; SD  =  standard deviation; HR  =  hazard ratio; CI  =  confidence interval; WHtR  =  waist-to-height-ratio; HbA1c  =  hemoglobin A1c; IGF-1  =  Insulin-like growth factor 1; hsCRP  =  high-sensitive C-reactive protein; UACR  =  urinary albumin-to-creatinine ratio; Cox regression analysis with backward elimination with a p-value of 0.05.

^*Conventional cardiovascular risk factors were forced into the model.