Table 5. Prediction of all-cause death by backward-elimination.

	HR (95%CI)*	p
Conventional cardiovascular risk factors
age, per year	1.10 (1.09; 1.11)	<.001
Smoker	2.17 (1.66; 2.84)	<.001
Antihypertensive medication	1.20 (0.93; 1.54)	0.16
HDL cholesterol, 1-SD increase	0.99 (0.87; 1.12)	0.86
Female	0.51 (0.39; 0.65)	<.001
Diabetes	1.79 (1.34; 2.38)	<.001
Systolic BP, 1-SD increase	1.03 (0.91; 1.16)	0.66
Total cholesterol, 1-SD increase	1.11 (0.98; 1.25)	0.09
Biomarkers
hsCRP, 1-SD increase	1.29 (1.15; 1.45)	<.001
IGF-1 <10th percentile	1.49 (1.08; 2.07)	0.02

BP  =  blood pressure; SD  =  standard deviation; HR  =  hazard ratio; CI  =  confidence interval; WHtR  =  waist-to-height-ratio; HbA1c  =  hemoglobin A1c; IGF-1  =  Insulin-like growth factor 1; hsCRP  =  high-sensitive C-reactive protein; UACR  =  urinary albumin-to-creatinine ratio; Cox regression analysis with backward elimination with a p-value of 0.05.

^*Conventional cardiovascular risk factors were forced into the model.