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. 2012 Mar 16;7(3):e33435. doi: 10.1371/journal.pone.0033435

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Tian et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(a) Establishments of food-, morphine- and cocaine-CPP. *p<0.05, postconditioning in comparison with preconditioning within the same group; # p<0.05 in comparison with saline group during postconditioning (n = 16 for saline; n = 20 for food; n = 18 for morphine, and n = 18 for cocaine); (b) Changes of global DNA methylation level in the PFC, and in the NAc following cocaine- and morphine CPP. *p<0.05 in comparison with saline group (n = 16 for saline; n = 9 for morphine and cocaine); (c) Food-CPP training did not change the global DNA methylation (n = 10). Data are depicted as the percentage of methylated cytosine in total cytosine. Data are expressed as mean±SEM.