Skip to main content
. 2012 Mar 16;7(3):e33435. doi: 10.1371/journal.pone.0033435

Figure 3. Effects of methionine on global DNA hypomethylation.

Figure 3

(a) Methionine reversed global DNA hypomethylation induced by cocaine-CPP; (b) Methionine did not affect global DNA methylation in morphine-CPP groups; (c) Methionine did not affect global DNA methylation in food-CPP groups. *p<0.05 in comparison with S-S group. Data are expressed as mean ± SEM. [S-S: n = 8; M-S: n = 7; S-C: n = 10(20 mg/kg), n = 7(5 mg/kg); M-C: n = 10 (20 mg/kg), n = 6(5 mg/kg); S-M: n = 10; M-M: n = 8; S-F: n = 10; M-F: n = 8].