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. 2012 Mar 16;7(3):e33534. doi: 10.1371/journal.pone.0033534

Figure 3. Lack of involvement of Tregs in the reduced CIA of CD38 KO mice.

Figure 3

(A) Number of Tregs in the lymph nodes of WT and CD38 KO mice non-immunized (NI; •) and 3 weeks after immunization with col-II-CFA (○). Representative results of 3 independent experiments are expressed as the values of individual mice. Bars represent the mean value of each examination. (B) Clinical severity of CIA 7 weeks after immunization with col II-CFA in PBS-treated or Treg-depleted WT and CD38 KO mice Representative results of 2 independent experiments are expressed as the values of individual mice are expressed. Bars represent the mean value of each examination. C) Number of iNKT cells in the spleen of WT mice and CD38 KO mice before (day 0) and 15 and 30 days after col II immunization. Results are expressed as mean ± SD. Statistic differences are indicated as follow: ns: non-significant, *p<0.05, **p<0.01, ***p<0.001.