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. 2012 Mar 16;7(3):e33409. doi: 10.1371/journal.pone.0033409

Figure 5. Effect of genetic background on survival in different mutant SOD1 transgenic mouse lines.

Figure 5

(A) Survival curves for C57BL/6 (B6) congenic SOD1G93A transgenic female mice (B6_G93A F) (closed circle: n = 19) and FVB/N (FVB) congenic SOD1G93A transgenic female mice (FVB_G93A F) (open square: n = 20). (B) Survival curves for B6 congenic SOD1G93A transgenic male mice (B6_G93A M) (closed circle: n = 15) and FVB congenic SOD1G93A transgenic male mice (FVB_G93A M) (open square: n = 17). (C) Survival curves for B6 congenic SOD1H46R transgenic female mice (B6_H46R F) (closed circle: n = 31) and FVB congenic SOD1H46R transgenic female mice (FVB_H46R F) (open square: n = 20). (D) Survival curves for B6 congenic SOD1H46R transgenic male mice (B6_H46R M) (closed circle: n = 63) and FVB congenic SOD1H46R transgenic male mice (FVB_H46R M) (open square: n = 27). Kaplan-Meier analysis with Log-rank (Mantel-Cox) test identifies significant differences in survival for mutant SOD1 transgenic lines between B6 and FVB backgrounds (p<0.0001).