Figure 1. Inflammatory reaction of endothelial cells in response to exposure to different blood products.

Concentrations of interleukin-6, IL-6 (A), interleukin-8 (IL-8) (B) as well as chemokine ligand 1 CXCL1 (C) in supernatants of human microvascular endothelial cells (HMVEC). HMVEC were stimulated with lipopolysaccharide (LPS) 2 µg/ml for 6 h (pre-stimulated) or not (unstimulated), followed by an 24 h-incubation with the according blood products packed red blood cells (PRBC), platelet concentrates (PC), pooled or apheresis, and solvent detergent or untreated fresh frozen plasma (FFP). Supernatants were collected and IL-6, IL8 and CXCL1 were determined. Results are shown as medians with interquartile ranges.