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. 2012 Mar 16;7(3):e33596. doi: 10.1371/journal.pone.0033596

Figure 7. LBP pre-treatment reduced both nitrosative stress and lipid peroxidation in cerebral ischemic penumbra after MCAO.

Figure 7

(A1–A3) Immunohistochemistry of nitrotyrosine (NT). Increased immunoreactivity of NT was noted in vehicle-treated brains after MCAO (arrows, A1). However, minimal NT signal was found in LBP groups (A2 & A3). (B1–B3) Immunohistochemistry of poly(ADP-ribose) (PAR). A profound PAR expression was observed in vehicle-treated brains (arrows, B1). With LBP treatment (LBP10), PAR immunoreactivity was much reduced (B3). (C & D) Semi-quantification of IHC (C, NT; D, PAR). * P<0.05, Kruskal-Wallis followed by Dunn's multiple comparison test, n = 5–7 for all groups. Scale bars = 25 µm.