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(A–C) MMP-9 IHC signals in endothelial cells along vessels in ipsilateral penumbral areas (interaural 1.98 mm). Note the intense MMP-9 staining in vehicle-treated vessels after MCAO (arrow, A), which was reduced in both LBP groups (arrows, B&C). Scale bar = 25 µm. (D) Semi-quantification of immunoreactivity of MMP-9. *P<0.05, LBP10 vs. Vehicle, Kruskal-Wallis followed by Dunn's multiple comparison test, n = 5 each group.
