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. Author manuscript; available in PMC: 2013 Mar 16.
Published in final edited form as: J Org Chem. 2012 Mar 6;77(6):2966–2970. doi: 10.1021/jo202686p

Table 1.

Optimization

graphic file with name nihms361774u2.jpg
entry catalyst ligand yield (%) a
1 Pd(OAc)2 RuPhos 57
2 Pd(OAc)2 SPhos 41
3 Pd(OAc)2 XantPhos 23
4 Pd(OAc)2 BINAP 55
5 Pd2(dba)3 RuPhos 62
6 Pd(PPh3)4 - 29
7 Pd(PPh3)2Cl2 PPh3 44
8 PEPPSI - 89

Benzyl chloride (0.2 mmol), potassium cyclopropyltrifluoroborate (0.35 mmol), Pd catalyst (0.01 mmol), ligand (0.02 mmol), K2CO3 (0.4 mmol), toluene/H2O 3:1 (0.1 M), 120 °C.

a

GC/MS yield determined using dodecane as the internal standard.