Table 2.
entry | benzyl chloride | catalytic system | GC/MS yield (%) a |
---|---|---|---|
1 | Pd2(dba)3 / RuPhos | 93 | |
2 | PEPPSI | 75 | |
3 | Pd2(dba)3 / RuPhos | 92 | |
4 | PEPPSI | 96 |
Benzyl chloride (0.2 mmol), potassium cyclopropyltrifluoroborate (0.35 mmol), Pd catalyst (0.01 mmol), ligand (0.02 mmol), K2CO3 (0.4 mmol), toluene/H2O 19:1 (0.1 M), 120 °C.
GC/MS yield determined using dodecane as the internal standard.