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. Author manuscript; available in PMC: 2013 Apr 15.
Published in final edited form as: Exp Cell Res. 2012 Feb 3;318(7):800–808. doi: 10.1016/j.yexcr.2012.01.024

Figure 4. Effects of vascular endothelial growth factors on the monolayer of lymphatic endothelial cells and sarcoma cells.

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Figure 4

VEGF-D at 10−8, 10−7 g/ml and VEGF-C at 10−7 g/ml significantly augmented the transendothelial migration of HT1080 cells through a lymphatic endothelial monolayer compared with the control (a). Representative images of control (b), VEGF-C (c) and VEGF-D (d) at 10−8 g/ml are shown. VEGF-D at 10−7 g/ml, but not VEGF-C, significantly increased the transendothelial migration of HuO9 cells (e). Neither VEGF-C nor -D increased the number of HT1080 cells (f) and HuO9 cells (g) migrating through the pores of the Transwell® membrane compared with the control. (N=5) Error bars indicate standard deviation. Bars on photographs indicate 100µm.