Table 1.

Compounds that increase lifespan and modulate protein aggregation in C. elegans

Compound	Increase in LS	Model of aggregation	Potential Mechanism	Reference
EGb761	8%	Aβ toxicity	Stress resistance	Wu et al. 2006
Reserpine	31%	Aβ toxicity	Stress resistance, requires Ser	Srivastava et al. 2008
Trehalose	30%	PolyQ toxicity, lipofuscin	Stress resistance, DAF-16 dependent	Honda et al. 2010
Metformin	40%	AGE pigments	DR mimetic, SKN-1 dependent	Onken et al. 2010
Thioflavin T	45%	Aβ and PolyQ toxicity	Protein homeostasis HSF-1 and SKN-1	Alavez et al. 2011
Curcumin	30%	Aβ and PolyQ toxicity	Protein homeostasis	Alavez et al. 2011
Rifampicin	30%	Aβ and PolyQ toxicity	Protein homeostasis
Celecoxib	10–20%	PolyQ toxicity	COX-2 inhibition, DAF-16 dependent	Ching et al. 2011
Ferulsinaic acid	18–22%	AGE pigments	Stress resistance	Sayed 2011
NG-094	20% (polyQ)	PolyQ toxicity	HSF-1 dependent	Haldimann et al. 2011