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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Dec 21;260(1):1–16. doi: 10.1016/j.taap.2011.12.014

Table 1.

Comparison of crystalline and amorphous forms of various metals and the level at which they were endocytized by cells

Metal Mean
Particle
size
(μm)
Concentration
(μg/ml)
Concentration
(μg/cm2
growth area)
Cells with
endocytized
particles (%)
Crystalline
Ni3S2
3.75 5 NA 12.5
3.75 10 NA 23.0
Crystalline NiS 3.20 5 2 12.5
3.20 10 4 22
Amorpous NiS 3.35 5 NA .1
3.35 10 NA .3
Amorphous
CoS
2 1 0.13 0.7
2 5 0.63 0.9
2 10 1.27 1.9
Crystalline
CoS2
1.25 1 0.13 7.2
1.25 5 0.63 28.1
1.25 10 1.27 49.3
Amorphous
CuS
0.98 1 0.13 1.6
0.98 10 1.27 6
Crystalline CuS 0.76 5 0.63 21.4
0.76 10 1.27 43.8
Amorphoud
CdS
0.64 1 0.13 <1
0.64 5 0.63 <1
Crystalline CdS 0.64 1 0.13 8.3
0.64 5 0.63 12.1

All cells were CHO cells treated for 24 hours.

Costa et al. 1982 (Co, Cu, and Cd); Costa et al. 1981b (Ni)