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. Author manuscript; available in PMC: 2013 Mar 16.
Published in final edited form as: ACS Chem Biol. 2012 Jan 17;7(3):506–517. doi: 10.1021/cb200440y

Figure 7. The entire C321 loop from APOBEC3G is required to sensitize APOBEC3A to chemical inhibition.

Figure 7

a) Alignment of the loop 6 regions of A3G (NP_068594.1), A3A (NP_663745.1) and A3A loop6 swap mutant by ClustalW2. The loop 6 region is shaded light gray and C321 is underlined. The secondary structure is derived from the A3G catalytic domain crystal structure (PDB ID: 3IR2) (17).

b) DNA deaminase activity data of the indicated recombinant proteins. The activity in the presence of DMSO carrier was set to 100% for each protein to facilitate comparison, and the relative mean activities are presented with SD.