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ARN-509 and MDV3100 were measured in plasma- or brain-tissue following 28d daily-dosing at 10 mg/kg/day. Plasma and brain were isolated 24h after final-dose on d28. ARN-509 and MDV3100 levels quantified using an LC/MS method.
| Dose (mg/kg/day) | # mice | a Plasma C24hr (μg/mL) | a Brain C24hr (μg/g) | Brain:Plasma (%) | |
|---|---|---|---|---|---|
| ARN-509 | 10 | 8 | 1.64 ± 0.30 | 0.479 ± 0.132 | 29.3 ± 6.3 |
| MDV3100 | 10 | 5 | 10.5 ± 2.3 | 2.01 ± 0.83 | 18.8 ± 4.4 |
mean
