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. Author manuscript; available in PMC: 2013 Mar 16.
Published in final edited form as: ACS Chem Biol. 2012 Jan 26;7(3):518–525. doi: 10.1021/cb2004725

Figure 3.

Figure 3

Adhesion to the surface functionalized with small molecule 3 is mediated by the αvβ3 integrin. a) Binding of recombinant αvβ3, αvβ5, or α5β1 integrin to 3 was assessed using surface plasmon resonance spectroscopy. b) Percent inhibition of M21 cell binding to the indicated surfaces in the presence of antibodies that block either the αvβ3 or the β1 integrins as measured by a luminescence assay (100 minus the average ratio of the mean luminescence of cell lysates plated in the presence of a blocking antibody versus those without antibody). Error bars represent the standard deviation (n=3 biological replicates).