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In vitro analyses of EGFR exon 19 insertion mutations. (A) Ba/F3 cells harboring different exon 19 insertions are sensitive to gefitinib and afatinib, similar to exon 19 deletion (E746_A750del) Ba/F3 cells. Exon 20 insertion cells (Y764_V765insHH) are resistant to both drugs. (B) NIH-3T3 cells harboring exon 19 insertions demonstrate a marked reduction in phospho-EGFR when treated with either gefitinib or afatinib, consistent with the growth assays (A).
