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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Curr Opin Microbiol. 2011 Dec 10;15(2):169–174. doi: 10.1016/j.mib.2011.11.008

Figure 1. Iron metalloregulation in Gram-positive pathogens.

Figure 1

Fur/DtxR iron-sensors are highlighted in yellow. The figure displays their most common function as iron-responsive repressors; however, these proteins can also act as activators in certain instances. Various physiological processes and proteins known to be regulated in response to iron fluctuations in one or more of the organisms highlighted in this review are depicted. Red coloration indicates that these proteins or processes are up-regulated under iron limitation while blue indicates repression in low iron. Black circles represent iron atoms and orange diamonds are heme.