Table 2.
CP-320626 Interrupted Protein Synthesis Rate*
| Protein Name | Fraction of New Protein Synthesis Caused by CP-320626(μM)
|
Expression Change | |||
|---|---|---|---|---|---|
| 25 | 50 | 100 | 15N only | ||
| Glyceraldehyde-3-phosphate dehydrogenase | 58% | 53% | 50% | 65% | Down-regulated |
| Heterogeneous nuclear ribonucleoprotein H | 66% | 62% | 60% | 69% | Down-regulated |
| 40S ribosomal protein SA | 27% | 33% | 28% | 38% | Down-regulated |
| Annexin A1 | 57% | 50% | 42% | 52% | Down-regulated |
| Phosphoglycerate mutase 1 | 49% | 44% | 42% | 49% | Down-regulated |
| Macrophage migration inhibitory factor | 50% | 48% | 50% | 53% | Down-regulated |
| Heterogeneous nuclear ribonucleoproteins A2/B1 | 63% | 76% | 74% | 58% | Up-regulated |
| Nucleoside diphosphate kinase A | 47% | 56% | 54% | 52% | Up-regulated |
| Calreticulin | 57% | 55% | 53% | 55% | Up-regulated |
*
Protein synthesis rate is expressed as percent new synthesis in 48 hours.