Figure 3.

IPBN is identified separately and in association with IHCC, demonstrating areas of low and high-grade cellular atypia. A) Fluid filled cystic structure (i; low power) demonstrated progressive cellular atypia (ii and iii) arrowheads point to epithelium showing an atypical low grade columnar biliary epithelium (ii) and high grade region with large nuclei, prominent nucleoli and marked cellular atypia (iii). IPBN were found within the context of normal liver (A;iv). B) IPBN adjacent and contiguous with invasive IHCC. C) Smaller IPBN (i) displayed an intestinal type epithelium (ii; arrowhead indicates mucin producing cell).