Table 1. Patient Characteristics and Outcome.
Subject Number |
Age/Diagnosis | Transplant type/Center |
Time post-SCT for CMV reactivation |
Cell dose of CMV specific CTL( CD3+CMV CTL/kg) |
Number of infusions |
Immuno- suppression |
CMV CTL response/timing |
Changes in CMV DNA Levels Post- infusion over tIme |
---|---|---|---|---|---|---|---|---|
1 | 19 years /MDS | Haplo-TCD UCSF |
4weeks | 5×105 | 2 | No | Yes/4 weeks | 2000 to 100 3 weeks |
2 | 4 years/Hyper IgM syndrome |
Haplo-TCD UCSF |
2 weeks | 5×105 | 1 | No | No* | persistent viremia |
3 | 14 years/AML | MUD-unmod PSHMC |
4 weeks | 5×105 | 1 | CSA/prednis one |
Transient/3 weeks |
2200 to 0 3 weeks |
4 | 9 mo/SCID | Haplo-TCD UCSF |
8 months | 5×105 | 1 | No | Yes/6 weeks | 2054 to 0 2 weeks |
5 | 11 years/T cell lymphoblastic lymphoma |
Haplo-TCD LCH |
3 weeks | 2.5×105 | 2 | Plaquenil/ Prednisone |
Yes/4 weeks | Intermittent viremia post- infusion; CMV retinitis |
6 | 2 years/CID | Haplo-TCD UCSF |
1 week | 2.5×105 | 1 | No | Yes/4 weeks | 1500 to 0 1 week |
7 | 19/HLH | MUD-unmod KUMC |
1 week | 5×105 | 1 | Prednisone | Transient/3 weeks |
Viremia recurred after steroids used for presumed HLH |
AML: acute myelogenous leukemia; MDS: myelodysplastic syndrome; HLH: Hemophagocytic lymphohistiocytosis; (S)CID: (severe) combined immunodeficiency; Haplo: human leukocyte antigen haplo-identical, related donor; MUD: matched unrelated donor; TCD: T cell depleted; unmod: unmodified bone marrow. Centers: University of California at San Francisco-UCSF; Penn State Hershey Medical Center-PSHMC; Levine Children’s Hospital-LCH; University of Kansas Medical Center-KUMC.