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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: J Immunother. 2012 Apr;35(3):293–298. doi: 10.1097/CJI.0b013e31824300a2

Table 1. Patient Characteristics and Outcome.

Subject
Number
Age/Diagnosis Transplant
type/Center
Time post-SCT
for CMV
reactivation
Cell dose of
CMV specific
CTL( CD3+CMV
CTL/kg)
Number of
infusions
Immuno-
suppression
CMV CTL
response/timing
Changes in CMV
DNA Levels Post-
infusion over tIme
1 19 years /MDS Haplo-TCD
UCSF
4weeks 5×105 2 No Yes/4 weeks 2000 to 100
3 weeks
2 4 years/Hyper
IgM syndrome
Haplo-TCD
UCSF
2 weeks 5×105 1 No No* persistent viremia
3 14 years/AML MUD-unmod
PSHMC
4 weeks 5×105 1 CSA/prednis
one
Transient/3
weeks
2200 to 0
3 weeks
4 9 mo/SCID Haplo-TCD
UCSF
8 months 5×105 1 No Yes/6 weeks 2054 to 0
2 weeks
5 11 years/T cell
lymphoblastic
lymphoma
Haplo-TCD
LCH
3 weeks 2.5×105 2 Plaquenil/
Prednisone
Yes/4 weeks Intermittent
viremia post-
infusion; CMV
retinitis
6 2 years/CID Haplo-TCD
UCSF
1 week 2.5×105 1 No Yes/4 weeks 1500 to 0
1 week
7 19/HLH MUD-unmod
KUMC
1 week 5×105 1 Prednisone Transient/3
weeks
Viremia recurred
after steroids used
for presumed HLH

AML: acute myelogenous leukemia; MDS: myelodysplastic syndrome; HLH: Hemophagocytic lymphohistiocytosis; (S)CID: (severe) combined immunodeficiency; Haplo: human leukocyte antigen haplo-identical, related donor; MUD: matched unrelated donor; TCD: T cell depleted; unmod: unmodified bone marrow. Centers: University of California at San Francisco-UCSF; Penn State Hershey Medical Center-PSHMC; Levine Children’s Hospital-LCH; University of Kansas Medical Center-KUMC.