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Inhibition on proteasome activity and cell proliferation by curcumin analogs. (A) The purified 20S proteasome was incubated with the indicated concentrations of curcumin (CUR) or its analogs for 2 h, followed by the proteasomal chymotrypsin-like activity assay. (B) LNCaP cells were treated with different concentrations of curcumin (CUR) or its analogs for 48 h, followed by the MTT assay. All of the reagents were dissolved in water.
