Figure 4.

Parameter dependency of Cv-2 noise behaviour: noise change (positive and negative change corresponds to ‘noise increase’ and ‘noise decrease’, respectively) is calculated by considering the absence of Cv-2 as the baseline (% noise change = (Λ_Cv2=85 − Λ_Cv2=0)/Λ_Cv2=0 × 100). Noise change in the presence of Cv-2 is evaluated for Cv-2 = 85 with a target BR level of 20 molecules on the surface. (a) Histogram demonstrates that the majority of solutions result in a reduction in amplitude. (b) Parsing the result into classes based on parameter set index shows that Cv-2 regulation of fluctuation amplitude is highly parameter-dependent and shows increases (red), moderate to no change (blue) and decreases (green) in fluctuation amplitude. (c) Parameter-dependent changes in fluctuation amplitude are captured by the dimensionless form of the dissociation constants, defined as K_D = k_off/k_on × R_T.