Fig. 1.

Sequence similarity network for the putative dipeptide epimerases in the enolase superfamily. Each node represents a single sequence; edges represents connections with BLAST e-value better than the cutoff value shown in each panel. Enzymes whose sequences were available in 2006 are colored according to their computationally predicted specificity, using homology models and ligand docking (larger nodes). The previously characterized Ala-Glu epimerases from E. coli and B. subtilis are labeled.