Fig. 2.

Reduced ATM kinase activity causes reduced mobility and longevity. (A) Graphed is the average percent of WT, ATM⁸/+, and ATM⁸ flies that climbed more than 75% (green), 50% to 75% (blue), 25% to 50% (gray), or less than 25% (red) of the vial height in the indicated time. Unlabeled bars had values of less than 5%. Statistical analysis by one-way ANOVA indicated a significant difference at all time points between ATM⁸ and WT flies (P < 0.01). (B) Graphed is the average percent survival at the indicated number of days after eclosion with error bars (SEM) for three independent trials of WT, ATM⁸/+, and ATM⁸ flies. Dotted lines indicate the 50% survival point for each genotype.