Fig. 4.

Reduced ATM kinase activity causes up-regulation of AMP gene expression in glial cells. (A) Shown is qPCR analysis of mRNA expression in ATM⁸ heads after 0, 3, or 8 d at 25 °C that was normalized to age-matched WT heads. Asterisks represent P < 0.05 based on Student t test analysis. Shown are representative immunofluorescence images of WT (B–D) or ATM⁸/+ (E–G) brains stained for Repo and detecting the AttA::GFP reporter gene. Other AMP::GFP reporter genes are shown in Fig. S2.