Fig. 5.

ATM knockdown in glial cells, but not neurons, causes reduced mobility and longevity. Graphed is the average percent of Repo-GAL4 and Repo-ATMi flies (A) or Elav-GAL4 and Elav-ATMi flies (C) that climbed more than 75% (green), 50% to 75% (blue), 25% to 50% (gray), or less than 25% (red) of the vial height in the indicated time. Unlabeled bars had values of less than 5%. Statistical analysis by one-way ANOVA indicated a significant difference at all time points between Repo-ATMi and Repo-GAL4 flies (P < 0.01) but not between Elav-ATMi and Elav-GAL4 flies (P > 0.05). Fig. 2A shows WT fly climbing data. Graphed is the average percent survival at the indicated number of days posteclosion with error bars (SEM) for three independent trials of WT, Repo-GAL4, and Repo-ATMi flies (B) or WT, Elav-GAL4, and Elav-ATMi flies (D). Dotted lines indicate the 50% survival point for each genotype.