Fig. 5.

Lin28A overexpression inhibits hematopoiesis. Recipients were transplanted with progenitor-enriched BMCs transduced with MIG-Lin28A or MIG. Five weeks postreconstitution, the number of (A) white blood cells, (B) myeloid cells, (C) granulocytes, and (D) erythrocytes per milliliter in the blood were measured by flow cytometry. We did not observe an increase in B cells in the MIG-Lin28A animals. Data are pooled from two independent groups of MIG-Lin28A animals, each with seven to eight animals, and compared with MIG (six animals). Data shown graphically represent the mean and SEM.