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. Author manuscript; available in PMC: 2013 Feb 28.
Published in final edited form as: J Am Chem Soc. 2012 Feb 15;134(8):3912–3916. doi: 10.1021/ja212182q

Scheme 2.

Scheme 2

Thio-Proline Ligation with Two Pro(SH) Diastereomers.a

aKey: (a) 6 M Gn•HCl, 100 mM NaH2PO4, 50 mM TCEP, pH 7.5. P1: ALLVNSS−; P2: −WEPLN; Ar = 2-(ethyldithio)-phenyl; TCEP = tris(2-carboxyethyl)phosphine.