Table 2.
Scatchard analysis of [3H]bicuculline binding against bicuculline in the cerebral cortex of control and experimental rats
| Group | Bmax (fmoles/mg ptn) | Kd (nM) |
|---|---|---|
| C | 85.4 ± 4.5 | 1.7 ± 0.3 |
| E | 37.9 ± 3.9*** | 0.9 ± 0.1** |
| E+B | 75.0 ± 5.3@@@ | 1.2 ± 0.3 |
| E+D | 80.1 ± 6.1@@@ | 1.39 ± 0.1 |
| E+C | 76.5 ± 4.7@@@ | 1.38 ± 0.2 |
Values are mean ± SEM of 4-6 separate experiments. Each group consist of 6-8 rats ** p < 0.01, *** p < 0.001 when compared to control, @@ < 0.01, @@@ < 0.001 when compared to epileptic group. C- Control, E- Epileptic, E+B- Epileptic rats treated with Bacopa monnieri, E+D- Epileptic rats treated with Bacoside A and E+C- Epileptic rats treated with Carbamazepine.