. 2012 Feb 5;39(2):195–203. doi: 10.1007/s10928-012-9241-9

Table 1.

Overview of the pharmacokinetic properties of all the hypothetical drugs, paracetamol and morphine

Drug	Metabolic route^a	Lipophilicity (log P)^a	CL blood flow (%)^a	Max. CL liver diffusion (%)^a	Free fraction^a	Intrinsic clearance (L/min)^b	Molecular weight (g/moL)^b	Extraction ratio^c	N
Paracetamol	UGT1A6 (58%)	0.46	21	0	0.82	0.455	151.2	0.27
	Sulfation (29%)
	CYP2E1 (10%)
	Renal (3%)
Hypotheticals	UGT1A6 (65%)	0.46	10, 50, 90	10, 50, 90	0.05, 0.50, 0.95	0.17–164	96–865	0.0056–0.91	17
	Sulfation (35%)	0.46	10, 50, 90	10, 50, 90	0.05, 0.50, 0.95	0.17–164	96–865	0.0056–0.91	17
		1	10, 50, 90	10, 50, 90	0.05, 0.50, 0.95	0.17–164	185–600	0.017–0.89	14
		2	50, 90	10	0.05, 0.50, 0.95	2.40–171	370–667	0.074–0.72	6
Morphine	UGT2B7 (90.5%)	0.89	96	78	0.75	89.4	285.3	0.51
	CYP3A4 (5%)
	Renal (4.5%)
Hypotheticals	UGT2B7	0.89	10, 50, 90	10, 50, 90	0.05, 0.50, 0.95	0.17–164	144–446	0.055–0.90	15

^aPre-defined pharmacokinetic properties

^bParameters adapted in the model

^cResultant pharmacokinetic property