Table 1.
Demographic characteristics of the study population
| NOD2−/− | NOD2+/− | NOD2+/+ | Significance P value | |
|---|---|---|---|---|
| Male n (%) | 41 (53%) | 35 (45%) | 1 (1.3%) | 0.634 |
| Median age at diagnosis (year) | 30.1 (14–59) | 26.4 (15–48) | 18 | 0.712 |
| Disease location (n and %) (Vienna) | ||||
| Ileal disease: L1 | 26/118 (22.1%) | 21/68 (30.9%) | 0.1076 | |
| Colonic disease: L2 | 10 (8.2%) | 3 (4.1%) | 0.09 | |
| Ileocolonic disease: L3 | 59 (50.8%) | 33 (48.8%) | 1 | 0.7966 |
| Upper gastrointestinal involvement | 15 (13.1%) | 2 (3.1%) | <0.05 | |
| Anal involvementa | 24 (21.1%) | 10 (14%) | 1 | 0.134 |
| Disease behavior (n and %) Vienna | ||||
| Inflammatory (B1) | 48 (41%) | 34 (50.5%) | 1 | 0.356 |
| Stricturing (B2) | 16 (14%) | 19 (28.2%) | 1 | 0.08 |
| Penetrating (B3) | 53 (45%) | 20 (29%) | 1 | <0.05 |
| Need for IBD surgery | 52 (44%) | 49 (72%) | 1 | <0.05 |
| History of smoking | 63 (53%) | 31 (45%) | Not significant | |
| Extraintestinal manifestations | 39 (33%) | 24 (35%) | Not significant | |
| p.Arg702Trp | 31 | |||
| p.Gly908Arg | 34 | 1 | ||
| p.Leu1007fsX1008 | 18 | |||
a(L1) + (L3) + (L4 − patients with ileal involvement)