Table 4.
Brain areas showing significantly lower perfusion in mild AD and MCI patients compared to controls.
| Group comparison |
Region | Cluster size (num.voxels) |
Coordinates (X, Y, Z) |
Z scores of maximum |
p(FDR) Cluster |
p(FDR) Voxel |
|---|---|---|---|---|---|---|
| AD<EC | Temporal pole and parahippocampal (R) | 418 | 45 21 −21 | 5.52 | 0.0001 | 0.001 |
| Angular gyrus, parietal, supramarginalis (R) | 200 | 45 −57 39 | 4.65 | 0.002 | 0.004 | |
| Temporal pole (L) | 86 | −36 18 −27 | 4.02 | 0.055 | 0.015 | |
| Middle and posterior cingulate (Bil) | 73 | 0 −42 33 | 4.46 | 0.083 | 0.006 | |
| MCI<EC | Middle and posterior cingulate (Bil) | 63 | −3 −42 36 | 4.33 | 0.022 | 0.004 |
| (ROI) | ||||||
| AD<MCI | Temporal pole and parahippocampal (R) | 226 | 51 21 −9 | 4.16 | 0.014 | 0.005 |
| (ROI) | Angular gyrus, parietal, supramarginalis (R) | 173 | 60 −51 24 | 3.94 | 0.013 | 0.011 |
| Temporal pole (L) | 167 | −51 21 −12 | 3.67 | 0.048 | 0.016 |
AD: Alzheimer’s disease; EC: Elderly Controls; MCI: Mild Cognitive Impairment; ROI: Regions of interest; R: right; L:left; Bil: Bilateral.