Table 4.

Hazard Ratio for the Development of BRCA-Associated Breast Cancer After RRSO

Mutation	No. of Patients	No. of Women Electing RRSO	Mean FU (months)	No. of Breast Cancers After RRSO	No. of Women Electing Surveillance	Mean FU (months)	No. of Breast Cancers During Surveillance	Hazard Ratio	95% CI	P
BRCA1 and BRCA2	597	303	36.4	19	294	33.2	28	0.53	0.29 to 0.96	.036
BRCA1	368	190	36.3	15	178	34.0	19	0.61	0.30 to 1.22	.16
BRCA2	229	113	36.6	4	116	31.9	9	0.28	0.08 to 0.92	.036

Abbreviations: RRSO, risk-reducing salpingo-oophorectomy; FU, follow-up.