Table 2.
Odds Ratios (OR) and 95% confidence intervals (CI) for risk of pancreatic cancer by quintiles of folate, vitamins B6, B12, and methionine intake in a population-based case-control study, San Francisco Bay Area, California
| Nutrients Quintiles | Cases n (%) | Controls n (%) | OR† (95% CI) | OR‡ (95% CI) |
|---|---|---|---|---|
| Total folate (food and supplements), μg/day | ||||
| Q1 (<280) | 135 (26) | 340 (20) | 1.0 | 1.0 |
| Q2 (280-<363) | 100 (19) | 341 (20) | 0.69 (0.51-0.94) | 0.72 (0.53-0.98) |
| Q3 (363-<533) | 114 (22) | 340 (20) | 0.78 (0.58-1.05) | 0.86 (0.64-1.2) |
| Q4 (533-<738) | 102 (19) | 340 (20) | 0.70 (0.52-0.95) | 0.76 (0.56-1.04) |
| Q5 (≥738) | 74 (14) | 340 (20) | 0.57 (0.41-0.79) | 0.67 (0.48-0.93) |
| P-trend | .002 | 0.04 | ||
| Folate from food only, μg/day | ||||
| Q1 (<247) | 135 (26) | 340 (20) | 1.0 | 1.0 |
| Q2 (247-<295) | 112 (21) | 341 (20) | 0.77 (0.57-1.04) | 0.82 (0.61-1.1) |
| Q3 (295-<338) | 98 (19) | 339 (20) | 0.70 (0.51-0.94) | 0.78 (0.57-1.1) |
| Q4 (338-<396) | 89 (17) | 340 (20) | 0.64 (0.47-0.87) | 0.74 (0.53-1.0) |
| Q5 (≥396) | 91 (17) | 341 (20) | 0.66 (0.49-0.91) | 0.79 (0.57-1.1) |
| P-trend | 0.004 | 0.10 | ||
| Total vitamin B6 (food and supplements), mg/day | ||||
| Q1 (<1.9) | 118 (22) | 341 (20) | 1.0 | 1.0 |
| Q2 (1.9-<2.4) | 114 (22) | 340 (20) | 0.93 (0.74-1.2) | 0.97 (0.71-1.3) |
| Q3 (2.4-<3.7) | 117 (22) | 340 (20) | 0.92 (0.49-0.87) | 1.0 (0.75-1.4) |
| Q4 (3.7-<5.0) | 98 (19) | 340 (20) | 0.81 (0.43-0.77) | 0.90 (0.65-1.2) |
| Q5 (≥5.0) | 78 (15) | 340 (20) | 0.67 (0.43-0.77) | 0.76 (0.55-1.1) |
| P-trend | 0.01 | 0.12 | ||
| Vitamin B6 from food only, mg/day | ||||
| Q1 (<1.7) | 114 (22) | 341 (20) | 1.0 | 1.0 |
| Q2 (1.7-<1.9) | 103 (20) | 340 (20) | 0.86 (0.63-1.2) | 0.89 (0.64-1.2) |
| Q3 (1.9-<2.2) | 106 (20) | 340 (20) | 0.90 (0.66-1.2) | 0.99 (0.72-1.4) |
| Q4 (2.2-<2.5) | 101 (19) | 340 (20) | 0.87 (0.64-1.2) | 0.97 (0.70-1.3) |
| Q5 (≥2.5) | 101 (19) | 340 (20) | 0.92 (0.67-1.3) | 1.0 (0.75-1.4) |
| P-trend | 0.65 | 0.68 | ||
| Total vitamin B12 (food and supplements), mg/day | ||||
| Q1 (<4.2) | 84 (16 ) | 341 (20) | 1.0 | 1.0 |
| Q2 (4.2-<6.4) | 116 (22) | 340 (20) | 1.3 (0.96-1.8) | 1.4 (0.97-1.9) |
| Q3 (6.4-<10.1) | 113 ( 22) | 340 (20) | 1.3 (0.94-1.8) | 1.4 (0.99-1.9) |
| Q4 (10.1-<14.5) | 106 (20) | 340 (20) | 1.3 (0.91-1.8) | 1.3 (0.93-1.8) |
| Q5 (≥14.5) | 106 (20) | 340 (20) | 1.3 (0.90-1.7) | 1.3 (0.92-1.8) |
| P-trend | 0.31 | 0.26 | ||
| Vitamin B12 from food only, mg/day | ||||
| Q1 (<3.4) | 66 (13) | 341 (20) | 1.0 | 1.0 |
| Q2 (3.4-<4.4) | 86 (16) | 339 (20) | 1.3 (0.94-1.9) | 1.3 (0.92-1.9) |
| Q3 (4.4-<5.6) | 123 (23) | 340 (20) | 1.8 (1.3 -2.6) | 1.8 (1.3 -2.5) |
| Q4 (5.6-<7.5) | 115 (22) | 341 (20) | 1.8 (1.2 -2.5) | 1.7 (1.2 -2.5) |
| Q5 (≥7.5) | 135 (26) | 340 (20) | 2.1 (1.5 -2.9) | 1.9 (1.3 -2.6) |
| P-trend | <0.001 | 0.001 | ||
| Methionine intake, mg/day | ||||
| Q1 (<1443) | 101 (19) | 341 (20) | 1.0 | 1.0 |
| Q2 (1443-<1634) | 101 (19) | 340 (20) | 0.96 (0.70-1.3) | 1.0 (0.73-1.4) |
| Q3 (1634-<1830) | 125 (24) | 339 (20) | 1.2 (0.88-1.6) | 1.3 (0.92-1.7) |
| Q4 (1830-<2060) | 95 (18) | 340 (20) | 0.94 (0.68-1.3) | 1.0 (0.74-1.4) |
| Q5 (≥2060) | 103 (20) | 341 (20) | 1.0 (0.75-1.4) | 1.1 (0.77-1.5) |
| P-trend | 0.90 | 0.69 | ||
†
Adjusted for age (in 5-year group), sex, and total energy intake (quartiles)
‡
Additionally adjusted for body mass index, history of diabetes, smoking, and alcohol consumption.