Table 3.
Folate intake, Quintiles (μg/day) | Cases n (%) | Controls n (%) | OR† (95% CI) | OR‡ (95% CI) |
---|---|---|---|---|
Smoking status | ||||
Never smokers | ||||
Q1 (<280) | 40 (25) | 123 (19) | 1.0 | 1.0 |
Q2 (280-<363) | 38 (23) | 118 (18) | 0.92 (0.55-1.6) | 0.85 (0.50-1.4) |
Q3 (363-<533) | 35 (21) | 139 (21) | 0.70 (0.41-1.2) | 0.70 (0.41-1.2) |
Q4 (533-<738) | 30 (18) | 131 (20) | 0.66 (0.38-1.1) | 0.69 (0.40-1.2) |
Q5 (≥738) | 20 (12) | 141 (22) | 0.42 (0.23-0.76) | 0.43 (0.24-0.80) |
P-trend | 0.002 | 0.007 | ||
Ever smokers | ||||
Q1 (<280) | 95 (26) | 217 (21) | 1.0 | 1.0 |
Q2 (280-<363) | 62 (17) | 223 (21) | 0.59 (0.40-0.86) | 0.58 (0.40-0.85) |
Q3 (363-<533) | 79 (22) | 201 (19) | 0.84 (0.58-1.2) | 0.87 (0.60-1.2) |
Q4 (533-<738) | 72 (20) | 209 (20) | 0.73 (0.51-1.1) | 0.72 (0.49-1.0) |
Q5 (≥738) | 54 (15) | 199 (19) | 0.66 (0.44-0.98) | 0.70 (0.47-1.0) |
P-trend | 0.13 | 0.20 | ||
P for interaction | 0.11 | 0.12 | ||
Alcohol intake | ||||
0-1 drink/day | ||||
Q1 (<280) | 84 (27) | 219 (20) | 1.0 | 1.0 |
Q2 (280-<363) | 58 (19) | 222 (20) | 0.61 (0.41-0.91) | 0.61 (0.41-0.90) |
Q3 (363-<533) | 70 (22) | 218 (20) | 0.74 (0.50-1.1) | 0.78 (0.53-1.2) |
Q4 (533-<738) | 52 (17) | 217 (20) | 0.54 (0.36-0.82) | 0.55 (0.37-0.84) |
Q5 (≥738) | 49 (16) | 233 (21) | 0.54 (0.36-0.80) | 0.57 (0.38-0.87) |
P-trend | 0.003 | 0.01 | ||
>1 drink/day | ||||
Q1 (<280) | 50 (24) | 121 (20) | 1.0 | 1.0 |
Q2 (280-<363) | 42 (20) | 119 (20) | 0.80 (0.49-1.3) | 0.91 (0.55-1.5) |
Q3 (363-<533) | 44 (21) | 122 (21) | 0.89 (0.54-1.5) | 1.05 (0.63-1.8) |
Q4 (533-<738) | 48 (23) | 123 (21) | 0.88 (0.54-1.4) | 1.1 (0.66-1.8) |
Q5 (≥738) | 25 (12) | 107 (18) | 0.59 (0.34-1.0) | 0.76 (0.42-1.3) |
P-trend | 0.16 | 0.69 | ||
P for interaction | 0.54 | 0.35 | ||
Methionine intake, mg/day | ||||
Low (<1730) | ||||
Q1 (<280) | 88 (27) | 214 (21) | 1.0 | 1.0 |
Q2 (280-<363) | 60 (18) | 213 (21) | 0.65 (0.44-0.95) | 0.69 (0.46-1.0) |
Q3 (363-<533) | 73 (22) | 199 (20) | 0.83 (0.57-1.2) | 0.91 (0.62-1.3) |
Q4 (533-<738) | 59 (18) | 200 (20) | 0.69 (0.47-1.0) | 0.75 (0.50-1.1) |
Q5 (≥738) | 47 (14) | 194 (19) | 0.63 (0.42-0.95) | 0.74 (0.48-1.1) |
P-trend | 0.05 | 0.25 | ||
High (≥1730) | ||||
Q1 (<280) | 47 (24) | 126 (19) | 1.0 | 1.0 |
Q2 (280-<363) | 40 (20) | 128 (19) | 0.78 (0.47-1.3) | 0.79 (0.47-1.3) |
Q3 (363-<533) | 41 (21) | 141 (21) | 0.75 (0.45-1.2) | 0.81 (0.48-1.4) |
Q4 (533-<738) | 43 (22) | 140 (21) | 0.79 (0.48-1.3) | 0.87 (0.51-1.5) |
Q5 (≥738) | 27 (14) | 146 (21) | 0.50 (0.29-0.85) | 0.56 (0.32-0.97) |
P-trend | 0.02 | 0.09 | ||
P for interaction | 0.49 | 0.66 |
Adjusted for age (in 5-year group), sex, and total energy intake (quartiles)
Additionally adjusted for body mass index, history of diabetes, smoking (not included in analyses stratified by smoking), and alcohol consumption (not included in analyses stratified by alcohol intake)