Table 2.
miR-10a targets in pathways of potential relevance to AML.
| Cancer Census Genes | KEGG AML | KEGG apoptosis | KEGG cell cycle | G.O.C. -myeloid related | NPM1mut-AML gene array | |
|---|---|---|---|---|---|---|
| n = 366 | n = 57 | n = 62 | n = 124 | n = 80 | n = 53 | |
| ARNT | MLLT6 | PIK3CA | BAX | CCNB3 | KLF4 | CENTD1 |
| BCL6 | NF2 | RARA | BCL2L11 | CDK4 | NCOA6 | ITM2A |
| CDK4 | NONO | CASP9 | CDKN2A | PURB | RARA | |
| CREBBP | NR4A3 | FOXO3 | CREBBP | RASGRP4 | SPARC | |
| ERBB2 | PDE4DIP | IRAK4 | ORC1L | |||
| ERCC3 | PIK3CA | ORC2L | ||||
| FANCD2 | PTEN | ORDC5L | ||||
| FOXO3 | RARA | |||||
| FUS | RECQL4 | |||||
| HMGA2 | SSX2 | |||||
| MLLT10 | WRN | |||||
The genes listed in this table are those in each pathway that are also one of the 1071 permissively identified miR-10a targets. n refers to the number of genes in each pathway interrogated for miR-10a targets. The genes linked to each of the heading in this table are listed in supplemental section. The final column refers to genes that were down regulated in three mRNA gene expression profiling studies of NPM1mut-AML [15-17]. The genes denoted in bold are those that were also stringently identified by all 3 prediction programs. KEGG- Kyoto Encyclopaedia of Genes and Genomes. GOC.- Gene Ontology Consortium