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. Author manuscript; available in PMC: 2012 Mar 18.
Published in final edited form as: Ann Neurol. 2011 Jun;69(6):1026–1031. doi: 10.1002/ana.22343

Figure 1.

Figure 1

Amino acid sequences and cleavage sites of p3-Alcα and Aβ in human CSF. The amino acid sequences of p3-Alcα (black-underline) along with the sequences of p3 (gray double-underline) and Aβ40 (black double-underline) of APP. The major primary (black arrowheads) and secondary (black arrowheads) cleavage sites of Alcα1 are indicated together with those of APP (α, the cleavage site by α-secretase or ADAM 10/17; β, the cleavage site by β-secretase or BACE). Numbers on amino acids indicate their positions. The shaded area indicates the putative transmembrane region. Alc = alcadein; APP = amyloid β protein precursor; CSF = cerebrospinal fluid.