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. 2011 Oct 12;37(5):1092–1103. doi: 10.1038/npp.2011.226

Figure 4.

Figure 4

Effects of pretreatment with PEG-CCRQ CocE on FR5TO5 responding maintained by sucrose pellets. Number of ratios completed (upper panels) and rate of responding (responses per second; lower panels) during sessions that were preceded by the administration of PBS (filled circles), 10.0 mg/kg; IV (shaded circles), or 32.0 mg/kg; IV PEG-CCRQ CocE (open circles). Left panels represent responding that occurred immediately after PBS or PEG-CCRQ CocE administration, with saline injections delivered before components 1 through 4. Right panels represent responding during sessions that occurred 48 h after PBS or PEG-CCRQ CocE administration, with cumulative doses of cocaine (1.0, 3.2, 10.0, and 32.0 mg/kg; IP) administered before components 1 through 4. Data represent the mean±the standard error of the mean (SEM) number of ratios completed or responses per second (n=6) during each 25 min component. Points above extinction (EXT) refer responding that resulted in presentation of stimuli associated with pellet delivery, but no pellet. **p<0.01; ***p<0.001; +p<0.05; +++p<0.001. Significant difference in the number of ratios completed, or rate of responding between PEG-CCRQ CocE-treated rats and PBS-treated rats receiving cocaine (*), and PBS-treated rats not receiving cocaine (ie, 24 h prior) (+) were determined by two-way, repeated measures ANOVA with post hoc Bonferroni tests.