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. 2011 Dec 14;37(5):1192–1203. doi: 10.1038/npp.2011.304

Figure 3.

Figure 3

Dose-response effects of mephedrone (4MMC) on neurochemistry and locomotor behavior in male rats undergoing in vivo microdialysis in nucleus accumbens. 4MMC-treated rats received i.v. injections of 0.3 mg/kg at time zero, followed by 1.0 mg/kg 60 min later. Control rats received i.v. saline injections (1 ml/kg) on the same schedule. Data are mean±SEM for N=7 rats per group, expressed as a percentage of preinjection baseline values (% basal) for dopamine (DA, panel a), serotonin (5-HT, panel b), horizontal locomotor activity (HLA, panel c), and stereotypic movements (Stereo, panel d). Basal concentrations of dialysate DA and 5-HT were 2.39±0.51 and 0.25±0.03 pg/5 μl, respectively. Basal levels of HLA and Stereo were 170±15 cm/20 min and 131±15 moves/20 min, respectively. **p<0.01 or *p<0.05 vs saline control at the corresponding time point (Bonferroni post hoc test).