Figure 5.

γ-Aminobutyric acid type A (GABA_A) receptor activation-induced memory retrieval impairment correlates with extracellular signal-regulated kinase (ERK) phosphorylation. Fifteen minutes before the retention trial, muscimol (0.25 μg/μl/side) with U0126 (0.25 nmol/μl/side) or diazepam (10 μg/μl/side) with U0126 (0.25 nmol/μl/side) was administered bilaterally into the hippocampus. (a), Latency times measured during the retention trial were reduced by muscimol and U0126 or diazepam and U0126 administration. Data are presented as the means±SEM (n=8 per group). ^*p<0.05, compared with the vehicle-treated control group. (b), Immediately after the retention trial, the mice were killed for western blotting to measure pERK level in the hippocampus. Data are presented as the means±SEM (n=4 per group). ^*p<0.05, compared with the vehicle only-treated retrieval group.