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. 2011 Dec 14;37(5):1245–1256. doi: 10.1038/npp.2011.312

Figure 1.

Figure 1

Intra-nucleus accumbens (NAc) administration of the adenosine A2A agonist CGS 21680 dose-dependently blocked cocaine-induced reinstatement. (a) Average number of cocaine infusions in each 4 h session over the 3 week cocaine self-administration phase. (b) Extinction training was performed in 6 daily 4 h sessions. (c) The adenosine A2A receptor agonist, CGS 21680, dose-dependently reduced cocaine-induced active lever responding. (d) Injection sites of animals included in the data set. Number of animals per treatment group: 0.0 CGS/saline=17, 0.0 CGS/15 mg/kg cocaine=16, 0.5 ng CGS/15 mg/kg cocaine=6, 1.0 ng CGS/15 mg/kg cocaine=7, 2.5 ng CGS/15 mg/kg cocaine=13, 5.0 ng CGS/15 mg/kg cocaine=10, and 10.0 ng CGS/15 mg/kg cocaine=10. *Significant from 0.0 CGS/saline (p<0.0001 Bonferroni's post-test); #significant from 0.0 CGS/15 mg/kg cocaine (p<0.0001 Bonferroni's post-test).